Background Lesions during a 24-Month Observation Period in Connexin 32-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Remyelination in experimentally demyelinated connexin 32 knockout mice.
The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice. Euthanasia was performed ranging from 1, 2, 3, 7, 15, 21 to 30 days after injection. Histochemical, immunohistochemical, immunofluorescence and transm...
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...................................................................................................................... iv INTRODUCTION ...............................................................................................................1 DOPAMINERGIC PATHWAYS............................................................................1 BASAL GANGLIA .......................................
متن کاملStructural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32.
Mutations affecting the connexin 32 (Cx32) gene are associated with the X-linked form of the hereditary peripheral neuropathy Charcot-Marie-Tooth disease (CMTX). We show that Cx32-deficient mice develop a late-onset progressive peripheral neuropathy with abnormalities comparable to those associated with CMTX, thus providing proof of the critical role of Cx32 in the maintenance of peripheral ner...
متن کاملDefective vascular development in connexin 45-deficient mice.
In order to reveal the biological function(s) of the gap-junction protein connexin 45 (Cx45), we generated Cx45-deficient mice with targeted replacement of the Cx45-coding region with the lacZ reporter gene. Heterozygous Cx45(+/)(-) mice showed strong expression of the reporter gene in vascular and visceral smooth muscle cells. Cx45-deficient embryos exhibited striking abnormalities in vascular...
متن کاملAltered connexin expression and wound healing in the epidermis of connexin-deficient mice.
To analyze the effect of connexin loss on the repair of wounded tail skin, we have studied the following transgenic mouse mutants: connexin30-/-, connexin31-/- and connexin43Cre-ER(T)/fl (for inducible deletion of the connexin43 coding region). Connexin43 and connexin31 are expressed in the basal and spinous layers of wild-type epidermis, whereas connexin31 and small amounts of connexin30, as w...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2013
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.12-0280